Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalSkin Pharmacology and Physiology
Issue number3
Publication statusPublished - 2018 May 1

Bibliographical note

Funding Information:
This study was supported by the R&D program of MSIP/ COMPA (2016K000225, Development of minimal pain multi-micro lancets for one-touch-smart diagnostic sensor) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare, Republic of Korea (grant No.: HI16C0625). In addition, C. Lee is grateful for financial support from the Hyundai Motor Chung Mong-Koo Foundation.

Publisher Copyright:
© 2018 S. Karger AG, Basel.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Dermatology


Dive into the research topics of 'Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches'. Together they form a unique fingerprint.

Cite this