Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Chisong Lee; Younghyon Andrew Eom; Huisuk Yang; Mingyu Jang; Sang Uk Jung; Ye Oak Park; Si Eun Lee; Hyungil Jung

doi:10.1159/000487401

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

Original language	English
Pages (from-to)	163-171
Number of pages	9
Journal	Skin Pharmacology and Physiology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1159/000487401
Publication status	Published - 2018 May 1

Bibliographical note

Funding Information:
This study was supported by the R&D program of MSIP/ COMPA (2016K000225, Development of minimal pain multi-micro lancets for one-touch-smart diagnostic sensor) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare, Republic of Korea (grant No.: HI16C0625). In addition, C. Lee is grateful for financial support from the Hyundai Motor Chung Mong-Koo Foundation.

Publisher Copyright:
© 2018 S. Karger AG, Basel.

All Science Journal Classification (ASJC) codes

Physiology
Pharmacology
Dermatology

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10.1159/000487401

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@article{9943a0b2867246d3bc700cdccd8dc477,

title = "Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches",

abstract = "Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.",

author = "Chisong Lee and Eom, {Younghyon Andrew} and Huisuk Yang and Mingyu Jang and Jung, {Sang Uk} and Park, {Ye Oak} and Lee, {Si Eun} and Hyungil Jung",

note = "Funding Information: This study was supported by the R&D program of MSIP/ COMPA (2016K000225, Development of minimal pain multi-micro lancets for one-touch-smart diagnostic sensor) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare, Republic of Korea (grant No.: HI16C0625). In addition, C. Lee is grateful for financial support from the Hyundai Motor Chung Mong-Koo Foundation. Publisher Copyright: {\textcopyright} 2018 S. Karger AG, Basel.",

year = "2018",

month = may,

day = "1",

doi = "10.1159/000487401",

language = "English",

volume = "31",

pages = "163--171",

journal = "Skin Pharmacology and Physiology",

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T1 - Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

AU - Lee, Chisong

AU - Eom, Younghyon Andrew

AU - Yang, Huisuk

AU - Jang, Mingyu

AU - Jung, Sang Uk

AU - Park, Ye Oak

AU - Lee, Si Eun

AU - Jung, Hyungil

N1 - Funding Information: This study was supported by the R&D program of MSIP/ COMPA (2016K000225, Development of minimal pain multi-micro lancets for one-touch-smart diagnostic sensor) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare, Republic of Korea (grant No.: HI16C0625). In addition, C. Lee is grateful for financial support from the Hyundai Motor Chung Mong-Koo Foundation. Publisher Copyright: © 2018 S. Karger AG, Basel.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

AB - Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

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JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

IS - 3

ER -

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

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