Abstract
Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.
Original language | English |
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Pages (from-to) | 639-641 |
Number of pages | 3 |
Journal | Nature Cell Biology |
Volume | 10 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2008 Jun |
All Science Journal Classification (ASJC) codes
- Cell Biology