Park et al. characterize transcriptome responses of colon cancer cells to 5FU-induced DNA damage at single-cell resolution. Many DNA damage response genes are heterogeneously expressed across the cell population. Specifically, cells undergoing different fates had distinct transcriptomic landscapes, characterized by the expression of fate-specific DNA damage response genes.
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)