Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

Sung Rye Park; Sim Namkoong; Leon Friesen; Chun Seok Cho; Zac Zezhi Zhang; Yu Chih Chen; Euisik Yoon; Chang H. Kim; Hojoong Kwak; Hyun Min Kang; Jun Hee Lee

doi:10.1016/j.celrep.2020.108077

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

Sung Rye Park, Sim Namkoong, Leon Friesen, Chun Seok Cho, Zac Zezhi Zhang, Yu Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee

Yonsei Advanced Science Institute

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Park et al. characterize transcriptome responses of colon cancer cells to 5FU-induced DNA damage at single-cell resolution. Many DNA damage response genes are heterogeneously expressed across the cell population. Specifically, cells undergoing different fates had distinct transcriptomic landscapes, characterized by the expression of fate-specific DNA damage response genes.

Original language	English
Article number	108077
Journal	Cell Reports
Volume	32
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.108077
Publication status	Published - 2020 Aug 25

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.108077

Cite this

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abstract = "Park et al. characterize transcriptome responses of colon cancer cells to 5FU-induced DNA damage at single-cell resolution. Many DNA damage response genes are heterogeneously expressed across the cell population. Specifically, cells undergoing different fates had distinct transcriptomic landscapes, characterized by the expression of fate-specific DNA damage response genes.",

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AU - Park, Sung Rye

AU - Namkoong, Sim

AU - Friesen, Leon

AU - Cho, Chun Seok

AU - Zhang, Zac Zezhi

AU - Chen, Yu Chih

AU - Yoon, Euisik

AU - Kim, Chang H.

AU - Kwak, Hojoong

AU - Kang, Hyun Min

AU - Lee, Jun Hee

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N2 - Park et al. characterize transcriptome responses of colon cancer cells to 5FU-induced DNA damage at single-cell resolution. Many DNA damage response genes are heterogeneously expressed across the cell population. Specifically, cells undergoing different fates had distinct transcriptomic landscapes, characterized by the expression of fate-specific DNA damage response genes.

AB - Park et al. characterize transcriptome responses of colon cancer cells to 5FU-induced DNA damage at single-cell resolution. Many DNA damage response genes are heterogeneously expressed across the cell population. Specifically, cells undergoing different fates had distinct transcriptomic landscapes, characterized by the expression of fate-specific DNA damage response genes.

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Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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