TY - GEN
T1 - Single cell migration chip using hydrodynamic cell positioning
AU - Chen, Yu Chih
AU - Lou, Xia
AU - Ingram, Patrick
AU - Yoon, Euisik
PY - 2011
Y1 - 2011
N2 - We report a cell migration chip which can monitor chemotaxis at single cell resolution. The chip uses a cell capturing scheme based on the difference in hydrodynamic resistance between flow paths and cellular valving. A high capture rate over 94% is achieved by optimizing the geometry of capture sites and the length of serpentine structures. After capturing, cell migration experiments induced by chemotaxis were carried out using the fabricated platform, and the behavior of each single cell was successfully traced.
AB - We report a cell migration chip which can monitor chemotaxis at single cell resolution. The chip uses a cell capturing scheme based on the difference in hydrodynamic resistance between flow paths and cellular valving. A high capture rate over 94% is achieved by optimizing the geometry of capture sites and the length of serpentine structures. After capturing, cell migration experiments induced by chemotaxis were carried out using the fabricated platform, and the behavior of each single cell was successfully traced.
UR - http://www.scopus.com/inward/record.url?scp=84860456448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860456448&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84860456448
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1409
EP - 1411
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -