Silicon-based thiourea-mediated and microwave-assisted thio-Michael addition under solvent-free reaction conditions

Kamalakannan Prabakaran, MacHindra Gund, Tae Kyu Kim, Euh Duck Jeong, Chae Young Oh, Fazlur Rahman Nawaz Khan, Jong Sung Jin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Silicon-based thiourea (SiliaBond® Thiourea) (Si-THU), a heterogeneous catalyst, has been applied to the highly selective C\-S bond formation via Michael addition of thiols to a,β-unsaturated carbonyl compounds under solvent-free conditions at 55-60°C. The thio-Michael addition products were obtained in an excellent yield under optimised conditions. This methodology involving a metal-free as well as a metal scavenger catalyst has been found to be an alternative method for the thio-Michael addition reaction.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalChemical Papers
Issue number5
Publication statusPublished - 2011 Oct

Bibliographical note

Funding Information:
Acknowledgements. We gratefully acknowledge financial support from the Department of Science and Technology, Government of India (Grant No. SR/FTP/CS-99/2006). The authors are grateful to the VIT University management for their generous support and facilities. We also wish to thank the SAIF, IIT Madras, Chennai for providing the NMR and MS facility.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Materials Chemistry


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