Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification

Mehdi Kheradmandfard; Seyed Farshid Kashani-Bozorg; Jung Seung Lee; Chang Lae Kim; Abbas Zarei Hanzaki; Young Sik Pyun; Seung Woo Cho; Auezhan Amanov; Dae Eun Kim

doi:10.1016/j.jallcom.2018.05.088

Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification

Mehdi Kheradmandfard, Seyed Farshid Kashani-Bozorg, Jung Seung Lee, Chang Lae Kim, Abbas Zarei Hanzaki, Young Sik Pyun, Seung Woo Cho, Auezhan Amanov, Dae Eun Kim

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

A novel β-type Ti–29Nb–13Ta–4.6Zr (TNTZ) alloy with a low Young's modulus, high bio-corrosion resistance, and excellent biocompatibility has been recently introduced for implant applications. Here, ultrasonic nanocrystal surface modification (UNSM) treatment was applied to TNTZ alloy to improve its wear resistance and biofunctionality. Application of UNSM to a TNTZ alloy resulted in the generation of a nanostructured surface layer. The wear resistance of the UNSM-treated specimen was observed to be more than 7 times higher than that of the untreated one. Cell culture tests indicated that MC3T3 cells adhered and spread more readily on the UNSM-treated specimen than on the untreated one. MTT assays after 1 and 4 days in culture also indicated enhancement of cell proliferation on the UNSM-treated specimen than that of the untreated one. Live/dead assay revealed no significant cytotoxicity in either substrate. The significant improvement of cell adhesion, spreading, and proliferation on the UNSM-treated TNTZ alloy specimen were attributed to both grain refinement and micro-patterned surface effects. These results demonstrate that UNSM-treatment not only improves the wear resistance of TNTZ alloy, but also enhances its biocompatibility, which makes it a strong candidate for applications in medical implants.

Original language	English
Pages (from-to)	941-949
Number of pages	9
Journal	Journal of Alloys and Compounds
Volume	762
DOIs	https://doi.org/10.1016/j.jallcom.2018.05.088
Publication status	Published - 2018 Sept 25

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government ( MSIT ) (No. 2010-0018289 ).

Publisher Copyright:
© 2018 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Mechanics of Materials
Mechanical Engineering
Metals and Alloys
Materials Chemistry

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10.1016/j.jallcom.2018.05.088

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Kheradmandfard, M., Kashani-Bozorg, S. F., Lee, J. S., Kim, C. L., Hanzaki, A. Z., Pyun, Y. S., Cho, S. W., Amanov, A., & Kim, D. E. (2018). Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification. Journal of Alloys and Compounds, 762, 941-949. https://doi.org/10.1016/j.jallcom.2018.05.088

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abstract = "A novel β-type Ti–29Nb–13Ta–4.6Zr (TNTZ) alloy with a low Young's modulus, high bio-corrosion resistance, and excellent biocompatibility has been recently introduced for implant applications. Here, ultrasonic nanocrystal surface modification (UNSM) treatment was applied to TNTZ alloy to improve its wear resistance and biofunctionality. Application of UNSM to a TNTZ alloy resulted in the generation of a nanostructured surface layer. The wear resistance of the UNSM-treated specimen was observed to be more than 7 times higher than that of the untreated one. Cell culture tests indicated that MC3T3 cells adhered and spread more readily on the UNSM-treated specimen than on the untreated one. MTT assays after 1 and 4 days in culture also indicated enhancement of cell proliferation on the UNSM-treated specimen than that of the untreated one. Live/dead assay revealed no significant cytotoxicity in either substrate. The significant improvement of cell adhesion, spreading, and proliferation on the UNSM-treated TNTZ alloy specimen were attributed to both grain refinement and micro-patterned surface effects. These results demonstrate that UNSM-treatment not only improves the wear resistance of TNTZ alloy, but also enhances its biocompatibility, which makes it a strong candidate for applications in medical implants.",

author = "Mehdi Kheradmandfard and Kashani-Bozorg, {Seyed Farshid} and Lee, {Jung Seung} and Kim, {Chang Lae} and Hanzaki, {Abbas Zarei} and Pyun, {Young Sik} and Cho, {Seung Woo} and Auezhan Amanov and Kim, {Dae Eun}",

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AU - Kheradmandfard, Mehdi

AU - Kashani-Bozorg, Seyed Farshid

AU - Lee, Jung Seung

AU - Kim, Chang Lae

AU - Hanzaki, Abbas Zarei

AU - Pyun, Young Sik

AU - Cho, Seung Woo

AU - Amanov, Auezhan

AU - Kim, Dae Eun

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government ( MSIT ) (No. 2010-0018289 ). Publisher Copyright: © 2018 Elsevier B.V.

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Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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