Short stature and ischemic stroke in nonvalvular atrial fibrillation: New insight into the old observation

Jeonggeun Moon, Hye Jeong Lee, Young Jin Kim, Jong Youn Kim, Hui Nam Pak, Jong Won Ha, Moon Hyoung Lee, Boyoung Joung

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background For decades, repeated epidemiologic observations have been made regarding the inverse relationship between stature and cardiovascular disease, including stroke. However, the concept has not been fully evaluated in patients with atrial fibrillation (AF). We investigated whether patient's height is associated with ischemic stroke in patients with nonvalvular AF and attempted to ascertain a potential mechanism. Methods All 558 AF patients were enrolled: 211 patients with ischemic stroke (144 men, 68 ± 10 years) and 347 no-stroke patients (275 men, 56 ± 11 years) as a control group. Clinical characteristics and echocardiographic parameters were compared between the two groups. Results (1) Stroke patients were shorter than those in the control group (164 ± 8, vs. 169 ± 8 cm, p < 0.001). However, body mass index failed to predict ischemic stroke; (2) Short stature (OR 0.93, 95% CI 0.91- 0.95, p < 0.001) along with left atrial (LA) anterior-posterior diameter and diastolic mitral inflow velocity (E) to diastolic mitral annuls velocity (E') (E/E') were independent predictor of stroke; (3) Height showed inverse correlation with E/E' independently, even after adjusting for other variables, including age, sex, and body weight, and comorbidities β - 0.20, p = 0.003); (4) LA size showed no correlation with stature (R = - 0.06, p = 0.18), whereas left ventricular size increases according to height of patients. Conclusions Short stature is associated with occurrence of ischemic stroke and diastolic dysfunction in patients with AF and preserved systolic function. Height is a non-modifiable risk factor of stroke and might be more important than obesity in Asian AF patients, who are relatively thinner than western populations.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 2014 Jul 1

Bibliographical note

Funding Information:
Funding Sources: This work was supported by research grants from the Gachon University Gil Medical Center , Republic of Korea (Grant number: 2013-10 and 2013-46 , J.M.), Boryung Pharmaceutical Company (J.M.), the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( NRF-2010-0021993, NRF-2012R1A2A2A02045367 , B.J.), and a grant from the Korean Healthcare Technology R&D project funded by the Ministry of Health & Welfare ( HI12C1552 , B.J.).

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Short stature and ischemic stroke in nonvalvular atrial fibrillation: New insight into the old observation'. Together they form a unique fingerprint.

Cite this