Shape deformation of the insula in schizophrenia

Dong Pyo Jang, Jae Jin Kim, Tae Sub Chung, Suk Kyoon An, Young Chul Jung, Jun Kee Lee, Jong Min Lee, In Young Kim, Sun I. kim

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Schizophrenia has been conceptualized to be a neurodevelopmental disorder. Neuroimaging evidence was generally findings of volumetric reductions in various brain structures. The shape analysis of the insula can uncover unique structural deformity in the neurodevelopmental disorder, which cannot be revealed from a simple volume measurement. The objective of this study was to demonstrate a subtle change of the insula in schizophrenia using our special shape analysis technique. Subjects were 23 patients with schizophrenia and 23 normal healthy subjects. A landmark-based structural and surface shape analysis of the insula was performed using high-spatial resolution magnetic resonance imaging. A characteristic finding was that the frontotemporal sides of the right insula were deformed in the patients with schizophrenia compared with normal controls. This deformation can be associated with abnormal development of the frontal and temporal lobes in schizophrenia.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
Issue number1
Publication statusPublished - 2006

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A040042), and the Korea Science and Engineering Foundation, interdisciplinary research (Contract grant number: R01-2002-000-00362-0).

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience


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