Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection

Hye Soo Kim; Seung Up Kim; Beom Kyung Kim; Jun Yong Park; Do Young Kim; Sang Hoon Ahn; Kwang Hyub Han; Young Nyun Park; Dai Hoon Han; Kyung Sik Kim; Jin Sub Choi; Gi Hong Choi; Hyon Suk Kim

doi:10.3350/cmh.2018.0073

Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection

Hye Soo Kim, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Hyub Han, Young Nyun Park, Dai Hoon Han, Kyung Sik Kim, Jin Sub Choi, Gi Hong Choi, Hyon Suk Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA⁺-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA⁺-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA⁺-M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA⁺-M2BP level >2.14 experienced recurrence more frequently than those with a WFA⁺-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA⁺-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA⁺-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA⁺-M2BP level into tailored postoperative surveillance strategies for patients with CHB.

Original language	English
Pages (from-to)	33-44
Number of pages	12
Journal	Clinical and Molecular Hepatology
Volume	26
Issue number	1
DOIs	https://doi.org/10.3350/cmh.2018.0073
Publication status	Published - 2020 Jan

Bibliographical note

Funding Information:
Graphics: The authors are grateful to Dong-Su Jang, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the figures. Writing assistance: The English in this document has been checked by at least two professional editors, both native speakers of English (www.textcheck.com). For a certificate, please see: http://www.textcheck.com/certificate/ESeGrC. This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2020 by Korean Association for the Study of the Liver.

All Science Journal Classification (ASJC) codes

Hepatology
Molecular Biology

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10.3350/cmh.2018.0073

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Kim, H. S., Kim, S. U., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Park, Y. N., Han, D. H., Kim, K. S., Choi, J. S., Choi, G. H., & Kim, H. S. (2020). Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection. Clinical and Molecular Hepatology, 26(1), 33-44. https://doi.org/10.3350/cmh.2018.0073

@article{05189ed7b48e41279232493ce825a33b,

title = "Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection",

abstract = "Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+-M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.",

author = "Kim, {Hye Soo} and Kim, {Seung Up} and Kim, {Beom Kyung} and Park, {Jun Yong} and Kim, {Do Young} and Ahn, {Sang Hoon} and Han, {Kwang Hyub} and Park, {Young Nyun} and Han, {Dai Hoon} and Kim, {Kyung Sik} and Choi, {Jin Sub} and Choi, {Gi Hong} and Kim, {Hyon Suk}",

note = "Funding Information: Graphics: The authors are grateful to Dong-Su Jang, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the figures. Writing assistance: The English in this document has been checked by at least two professional editors, both native speakers of English (www.textcheck.com). For a certificate, please see: http://www.textcheck.com/certificate/ESeGrC. This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2020 by Korean Association for the Study of the Liver.",

year = "2020",

month = jan,

doi = "10.3350/cmh.2018.0073",

language = "English",

volume = "26",

pages = "33--44",

journal = "Clinical and molecular hepatology",

issn = "2287-2728",

publisher = "Korean Association for the Study of the Liver",

number = "1",

}

Kim, HS, Kim, SU, Kim, BK, Park, JY , Kim, DY , Ahn, SH , Han, KH, Park, YN, Han, DH, Kim, KS, Choi, JS, Choi, GH & Kim, HS 2020, 'Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection', Clinical and Molecular Hepatology, vol. 26, no. 1, pp. 33-44. https://doi.org/10.3350/cmh.2018.0073

Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection. / Kim, Hye Soo; Kim, Seung Up; Kim, Beom Kyung et al.
In: Clinical and Molecular Hepatology, Vol. 26, No. 1, 01.2020, p. 33-44.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection

AU - Kim, Hye Soo

AU - Kim, Seung Up

AU - Kim, Beom Kyung

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Ahn, Sang Hoon

AU - Han, Kwang Hyub

AU - Park, Young Nyun

AU - Han, Dai Hoon

AU - Kim, Kyung Sik

AU - Choi, Jin Sub

AU - Choi, Gi Hong

AU - Kim, Hyon Suk

N1 - Funding Information: Graphics: The authors are grateful to Dong-Su Jang, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the figures. Writing assistance: The English in this document has been checked by at least two professional editors, both native speakers of English (www.textcheck.com). For a certificate, please see: http://www.textcheck.com/certificate/ESeGrC. This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2020 by Korean Association for the Study of the Liver.

PY - 2020/1

Y1 - 2020/1

N2 - Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+-M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.

AB - Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+-M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.

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Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection

Abstract

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