Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1)

Moo Gak Hwang; In Kwon Chung; Bin Goo Kang; Myeon Haeng Cho

doi:10.1016/S0014-5793(01)02685-0

Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1)

Moo Gak Hwang, In Kwon Chung, Bin Goo Kang, Myeon Haeng Cho

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	FEBS Letters
Volume	503
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(01)02685-0
Publication status	Published - 2001 Aug 10

Bibliographical note

Funding Information:
This work was supported in part by Grant 1999-015-DP0389 and Grant 2000-015-DP0400 from the Korea Research Foundation.

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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abstract = "We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.",

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AU - Hwang, Moo Gak

AU - Chung, In Kwon

AU - Kang, Bin Goo

AU - Cho, Myeon Haeng

N1 - Funding Information: This work was supported in part by Grant 1999-015-DP0389 and Grant 2000-015-DP0400 from the Korea Research Foundation.

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AB - We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.

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Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1)

Abstract

Bibliographical note

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