Senescent T cells predict the development of hyperglycemia in humans

Yong ho Lee, So Ra Kim, Dai Hoon Han, Hee Tae Yu, Yoon Dae Han, Jin Hee Kim, Soo Hyun Kim, Chan Joo Lee, Byoung Hoon Min, Dong Hyun Kim, Kyung Hwan Kim, Jin Won Cho, Won Woo Lee, Eui Cheol Shin, Sungha Park

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
Issue number1
Publication statusPublished - 2019 Jan 1

Bibliographical note

Publisher Copyright:
© 2018 by the American Diabetes Association.

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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