Self-powered deep brain stimulation via a flexible PIMNT energy harvester

Geon Tae Hwang; Youngsoo Kim; Jeong Ho Lee; Sekwon Oh; Chang Kyu Jeong; Dae Yong Park; Jungho Ryu; Hyuksang Kwon; Sang Goo Lee; Boyoung Joung; Daesoo Kim; Keon Jae Lee

doi:10.1039/c5ee01593f

Self-powered deep brain stimulation via a flexible PIMNT energy harvester

Geon Tae Hwang, Youngsoo Kim, Jeong Ho Lee, Sekwon Oh, Chang Kyu Jeong, Dae Yong Park, Jungho Ryu, Hyuksang Kwon, Sang Goo Lee, Boyoung Joung, Daesoo Kim, Keon Jae Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

184 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) is widely used for neural prosthetics and brain-computer interfacing. Thus far in vivo implantation of a battery has been a prerequisite to supply the necessary power. Although flexible energy harvesters have recently emerged as alternatives to batteries, they generate insufficient energy for operating brain stimulation. Herein, we report a high performance flexible piezoelectric energy harvester by enabling self-powered DBS in mice. This device adopts an indium modified crystalline Pb(In_1/2Nb_1/2)O₃-Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ (PIMNT) thin film on a plastic substrate to transform tiny mechanical motions to electricity. With slight bending, it generates an extremely high current reaching 0.57 mA, which satisfies the high threshold current for real-time DBS of the motor cortex and thereby could efficiently induce forearm movements in mice. The PIMNT based flexible energy harvester could open a new avenue for future in vivo healthcare technology using self-powered biomedical devices.

Original language	English
Pages (from-to)	2677-2684
Number of pages	8
Journal	Energy and Environmental Science
Volume	8
Issue number	9
DOIs	https://doi.org/10.1039/c5ee01593f
Publication status	Published - 2015 Sept 1

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Publisher Copyright:
© The Royal Society of Chemistry 2015.

All Science Journal Classification (ASJC) codes

Environmental Chemistry
Renewable Energy, Sustainability and the Environment
Nuclear Energy and Engineering
Pollution

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10.1039/c5ee01593f

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abstract = "Deep brain stimulation (DBS) is widely used for neural prosthetics and brain-computer interfacing. Thus far in vivo implantation of a battery has been a prerequisite to supply the necessary power. Although flexible energy harvesters have recently emerged as alternatives to batteries, they generate insufficient energy for operating brain stimulation. Herein, we report a high performance flexible piezoelectric energy harvester by enabling self-powered DBS in mice. This device adopts an indium modified crystalline Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 (PIMNT) thin film on a plastic substrate to transform tiny mechanical motions to electricity. With slight bending, it generates an extremely high current reaching 0.57 mA, which satisfies the high threshold current for real-time DBS of the motor cortex and thereby could efficiently induce forearm movements in mice. The PIMNT based flexible energy harvester could open a new avenue for future in vivo healthcare technology using self-powered biomedical devices.",

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AU - Park, Dae Yong

AU - Ryu, Jungho

AU - Kwon, Hyuksang

AU - Lee, Sang Goo

AU - Joung, Boyoung

AU - Kim, Daesoo

AU - Lee, Keon Jae

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AB - Deep brain stimulation (DBS) is widely used for neural prosthetics and brain-computer interfacing. Thus far in vivo implantation of a battery has been a prerequisite to supply the necessary power. Although flexible energy harvesters have recently emerged as alternatives to batteries, they generate insufficient energy for operating brain stimulation. Herein, we report a high performance flexible piezoelectric energy harvester by enabling self-powered DBS in mice. This device adopts an indium modified crystalline Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 (PIMNT) thin film on a plastic substrate to transform tiny mechanical motions to electricity. With slight bending, it generates an extremely high current reaching 0.57 mA, which satisfies the high threshold current for real-time DBS of the motor cortex and thereby could efficiently induce forearm movements in mice. The PIMNT based flexible energy harvester could open a new avenue for future in vivo healthcare technology using self-powered biomedical devices.

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Self-powered deep brain stimulation via a flexible PIMNT energy harvester

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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