Self-confirming "aND" logic nanoparticles for fault-free MRI

Jin Sil Choi, Jae Hyun Lee, Tae Hyun Shin, Ho Taek Song, Eung Yeop Kim, Jinwoo Cheon

Research output: Contribution to journalArticlepeer-review

243 Citations (Scopus)


Achieving high accuracy in the imaging of biological targets is a challenging issue. For MRI, to enhance imaging accuracy, two different imaging modes with specific contrast agents are used; one is a T1 type for a positive MRI signal and the other is a T2 type for a negative signal. Conventional contrast agents respond only in a single imaging mode and frequently encounter ambiguities in the MR images. Here, we propose a magnetically decoupled core-shell design concept to develop a dual mode nanoparticle contrast agent (DMCA). This DMCA not only possesses superior MR contrast effects but also has the unique capability of displaying AND logic signals in both the T1 and T2 modes. The latter enables self-confirmation of images and leads to greater diagnostic accuracy. A variety of novel DMCAs are possible, and the use of DMCAs can potentially bring the accuracy of MR imaging of diseases to a higher level.

Original languageEnglish
Pages (from-to)11015-11017
Number of pages3
JournalJournal of the American Chemical Society
Issue number32
Publication statusPublished - 2010 Aug 18

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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