Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles

Hao Shen, Seungpyo Hong, Robert K. Prud'Homme, Ying Liu

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103 Citations (Scopus)


We present an experimental study of selfassembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). β-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO3)3) and potassium thiocyanate (KSCN) to precipitate Fe(SCN)(3-x)+x. Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flowpattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.

Original languageEnglish
Pages (from-to)4109-4120
Number of pages12
JournalJournal of Nanoparticle Research
Issue number9
Publication statusPublished - 2011 Sept

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Condensed Matter Physics
  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • General Materials Science
  • Modelling and Simulation


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