TY - GEN
T1 - Scalable multiplexed drug-combination screening platforms using 3D microtumor model for precision medicine
AU - Zhang, Zhixiong
AU - Urs, Sumithra
AU - Chen, Yu Chih
AU - Sangani, Karnik Bipin
AU - Simeone, Diane
AU - Yoon, Euisik
PY - 2016
Y1 - 2016
N2 - Drug combination treatment has emerged as a standard of care for many diseases including cancer. The chance of finding an appropriate drug combination for a certain patient increases with more target compounds under investigation. However, experimental complexity and cost grow exponentially as the number of drug candidates increases. Here, we report a scalable, easy-to-handle, high-throughput drug combination screening platform which enables screening of any possible dual-drug combinations from 8 different drugs with various concentration gradients.
AB - Drug combination treatment has emerged as a standard of care for many diseases including cancer. The chance of finding an appropriate drug combination for a certain patient increases with more target compounds under investigation. However, experimental complexity and cost grow exponentially as the number of drug candidates increases. Here, we report a scalable, easy-to-handle, high-throughput drug combination screening platform which enables screening of any possible dual-drug combinations from 8 different drugs with various concentration gradients.
UR - http://www.scopus.com/inward/record.url?scp=85014222184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014222184&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85014222184
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 643
EP - 644
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -
