Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels

In Seon Lee; Sae Byul Kim; Chan Soo Moon; Sung Mo Jung; Song Yee Kim; Eun Young Kim; Ji Ye Jung; Young Ae Kang; Young Sam Kim; Se Kyu Kim; Joon Chang; Moo Suk Park

doi:10.4046/trd.2012.73.6.320

Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels

In Seon Lee, Sae Byul Kim, Chan Soo Moon, Sung Mo Jung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright

Original language	English
Pages (from-to)	320-324
Number of pages	5
Journal	Tuberculosis and Respiratory Diseases
Volume	73
Issue number	6
DOIs	https://doi.org/10.4046/trd.2012.73.6.320
Publication status	Published - 2012 Dec

Bibliographical note

Funding Information:
Acknowledgements. This work was supported in part by the Neuro-Oncology Research Fund, the Royal Marsden NHS Trust and the Cancer Research Campaign. We are grateful to our neurosurgical colleagues for their continued collaboration. This work was undertaken by the Royal Marsden NHS Trust, who received a proportion of its funding from the NHS Executive. The views expressed are those of the authors and not necessarily those of the NHS Executive.

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2012.73.6.320

Cite this

Lee, I. S., Kim, S. B., Moon, C. S., Jung, S. M., Kim, S. Y., Kim, E. Y., Jung, J. Y., Kang, Y. A., Kim, Y. S., Kim, S. K., Chang, J., & Park, M. S. (2012). Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels. Tuberculosis and Respiratory Diseases, 73(6), 320-324. https://doi.org/10.4046/trd.2012.73.6.320

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title = "Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels",

abstract = "A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright",

author = "Lee, {In Seon} and Kim, {Sae Byul} and Moon, {Chan Soo} and Jung, {Sung Mo} and Kim, {Song Yee} and Kim, {Eun Young} and Jung, {Ji Ye} and Kang, {Young Ae} and Kim, {Young Sam} and Kim, {Se Kyu} and Joon Chang and Park, {Moo Suk}",

note = "Funding Information: Acknowledgements. This work was supported in part by the Neuro-Oncology Research Fund, the Royal Marsden NHS Trust and the Cancer Research Campaign. We are grateful to our neurosurgical colleagues for their continued collaboration. This work was undertaken by the Royal Marsden NHS Trust, who received a proportion of its funding from the NHS Executive. The views expressed are those of the authors and not necessarily those of the NHS Executive.",

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AU - Kim, Se Kyu

AU - Chang, Joon

AU - Park, Moo Suk

N1 - Funding Information: Acknowledgements. This work was supported in part by the Neuro-Oncology Research Fund, the Royal Marsden NHS Trust and the Cancer Research Campaign. We are grateful to our neurosurgical colleagues for their continued collaboration. This work was undertaken by the Royal Marsden NHS Trust, who received a proportion of its funding from the NHS Executive. The views expressed are those of the authors and not necessarily those of the NHS Executive.

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N2 - A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright

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Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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