Salivary biomarkers in oral squamous cell carcinoma

Truc Thi Hoang Nguyen, Buyanbileg Sodnom-Ish, Sung Weon Choi, Hyo Il Jung, Jaewook Cho, Inseong Hwang, Soung Min Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


In disease diagnostics and health surveillance, the use of saliva has potential because its collection is convenient and noninvasive. Over the past two decades, the development of salivary utilization for the early detection of cancer, especially oral cavity and oropharynx cancer has gained the interest of the researcher and clinician. Until recently, the oral cavity and oropharynx cancers are still having a five-year survival rate of 62%, one of the lowest in all major human cancers. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). Despite the ease of accessing the oral cavity in clinical examination, most OSCC lesions are not diagnosed in the early stage, which is suggested to be the main cause of the low survival rate. Many studies have been performed and reported more than 100 potential saliva biomarkers for OSCC. However, there are still obstacles in figuring out the reliable OSCC salivary biomarkers and the clinical application of the early diagnosis protocol. The current review article discusses the emerging issues and is hoped to raise awareness of this topic in both researchers and clinicians. We also suggested the potential salivary biomarkers that are reliable, specific, and sensitive for the early detection of OSCC.

Original languageEnglish
Pages (from-to)301-312
Number of pages12
JournalJournal of the Korean Association of Oral and Maxillofacial Surgeons
Issue number5
Publication statusPublished - 2020 Oct

Bibliographical note

Publisher Copyright:
Copyright © 2020 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery


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