TY - JOUR
T1 - Role of miRNAs in bone and their potential as therapeutic targets
AU - Kim, Kyoung Min
AU - Lim, Sung Kil
PY - 2014/6
Y1 - 2014/6
N2 - MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3′-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
AB - MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3′-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=84901982221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901982221&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2014.05.001
DO - 10.1016/j.coph.2014.05.001
M3 - Review article
C2 - 24907412
AN - SCOPUS:84901982221
SN - 1471-4892
VL - 16
SP - 133
EP - 141
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 1
ER -
