Role of HLA class II alleles in Korean patients with IDDM

H. C. Lee; H. Ikegami; T. Fugisana; T. Ogihara; S. W. Park; Y. S. Chung; J. O. Park; E. J. Lee; S. K. Lim; K. R. Kim; K. B. Huh; Y. S. Kim; D. S. Lee; D. H. Kim

doi:10.1016/0168-8227(96)01200-4

Role of HLA class II alleles in Korean patients with IDDM

H. C. Lee, H. Ikegami, T. Fugisana, T. Ogihara, S. W. Park, Y. S. Chung, J. O. Park, E. J. Lee, S. K. Lim, K. R. Kim, K. B. Huh, Y. S. Kim, D. S. Lee, D. H. Kim

Research output: Contribution to journal › Article › peer-review

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Abstract

MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1^∗0301 and DQA1^∗0501 were positively and DQA1^∗0102 and DQA1^∗0201 negatively associated with IDDM. DQB1^∗0301 and DQB1^∗0601 were negatively associated with IDDM. Heterodimers DQA1^∗0301-DQB1^∗0201, DQA1^∗0501-DQB1^∗0201 and DQA1^∗0501-DQB1^∗0302 were positively associated and DQA1^∗0102-DQB1^∗0601 negatively associated with IDDM. The frequencies of DR3-DQA1^∗0301-DQB1^∗0201 and -DQA1^∗0501-DQB1^∗0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1^∗0301-DQB1^∗0201 and DR9-DQA1^∗0301-DQB1^∗0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Diabetes Research and Clinical Practice
Volume	31
Issue number	1-3
DOIs	https://doi.org/10.1016/0168-8227(96)01200-4
Publication status	Published - 1996

Bibliographical note

Funding Information:
This study was supported by a development projectg rant and faculty funds from Yonsei University, College of Medicine for 1992.W e thank Dr. G.S. Eisenbarthf or valuablec riticism.

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0168-8227(96)01200-4

Cite this

@article{37545b62b38d4640a8aebf2c0224362a,

title = "Role of HLA class II alleles in Korean patients with IDDM",

abstract = "MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1∗0301 and DQA1∗0501 were positively and DQA1∗0102 and DQA1∗0201 negatively associated with IDDM. DQB1∗0301 and DQB1∗0601 were negatively associated with IDDM. Heterodimers DQA1∗0301-DQB1∗0201, DQA1∗0501-DQB1∗0201 and DQA1∗0501-DQB1∗0302 were positively associated and DQA1∗0102-DQB1∗0601 negatively associated with IDDM. The frequencies of DR3-DQA1∗0301-DQB1∗0201 and -DQA1∗0501-DQB1∗0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1∗0301-DQB1∗0201 and DR9-DQA1∗0301-DQB1∗0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.",

author = "Lee, {H. C.} and H. Ikegami and T. Fugisana and T. Ogihara and Park, {S. W.} and Chung, {Y. S.} and Park, {J. O.} and Lee, {E. J.} and Lim, {S. K.} and Kim, {K. R.} and Huh, {K. B.} and Kim, {Y. S.} and Lee, {D. S.} and Kim, {D. H.}",

note = "Funding Information: This study was supported by a development projectg rant and faculty funds from Yonsei University, College of Medicine for 1992.W e thank Dr. G.S. Eisenbarthf or valuablec riticism.",

year = "1996",

doi = "10.1016/0168-8227(96)01200-4",

language = "English",

volume = "31",

pages = "9--15",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Role of HLA class II alleles in Korean patients with IDDM

AU - Lee, H. C.

AU - Ikegami, H.

AU - Fugisana, T.

AU - Ogihara, T.

AU - Park, S. W.

AU - Chung, Y. S.

AU - Park, J. O.

AU - Lee, E. J.

AU - Lim, S. K.

AU - Kim, K. R.

AU - Huh, K. B.

AU - Kim, Y. S.

AU - Lee, D. S.

AU - Kim, D. H.

N1 - Funding Information: This study was supported by a development projectg rant and faculty funds from Yonsei University, College of Medicine for 1992.W e thank Dr. G.S. Eisenbarthf or valuablec riticism.

PY - 1996

Y1 - 1996

N2 - MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1∗0301 and DQA1∗0501 were positively and DQA1∗0102 and DQA1∗0201 negatively associated with IDDM. DQB1∗0301 and DQB1∗0601 were negatively associated with IDDM. Heterodimers DQA1∗0301-DQB1∗0201, DQA1∗0501-DQB1∗0201 and DQA1∗0501-DQB1∗0302 were positively associated and DQA1∗0102-DQB1∗0601 negatively associated with IDDM. The frequencies of DR3-DQA1∗0301-DQB1∗0201 and -DQA1∗0501-DQB1∗0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1∗0301-DQB1∗0201 and DR9-DQA1∗0301-DQB1∗0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

AB - MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1∗0301 and DQA1∗0501 were positively and DQA1∗0102 and DQA1∗0201 negatively associated with IDDM. DQB1∗0301 and DQB1∗0601 were negatively associated with IDDM. Heterodimers DQA1∗0301-DQB1∗0201, DQA1∗0501-DQB1∗0201 and DQA1∗0501-DQB1∗0302 were positively associated and DQA1∗0102-DQB1∗0601 negatively associated with IDDM. The frequencies of DR3-DQA1∗0301-DQB1∗0201 and -DQA1∗0501-DQB1∗0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1∗0301-DQB1∗0201 and DR9-DQA1∗0301-DQB1∗0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

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U2 - 10.1016/0168-8227(96)01200-4

DO - 10.1016/0168-8227(96)01200-4

M3 - Article

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AN - SCOPUS:0029893675

SN - 0168-8227

VL - 31

SP - 9

EP - 15

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 1-3

ER -

Role of HLA class II alleles in Korean patients with IDDM

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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