Risk factors for osteoporosis in chronic inflammatory demyelinating polyradiculoneuropathy

Seung Woo Kim, Young Chul Choi, Seung Min Kim, Ha Young Shin

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2 Citations (Scopus)


Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients possess multiple risk factors for osteoporosis, but few studies have evaluated bone mineral density (BMD) in CIDP patients. Methods: We retrospectively compared the BMD of CIDP patients with that of normal controls, and evaluated the clinical factors associated with osteoporosis. Results: Total BMD was lower in CIDP patients than in normal controls (P = 0.017). In a comparison of 16 osteoporotic CIDP patients with 25 non-osteoporotic patients, the cumulative prednisolone dose was lower (P = 0.022) and the duration from disease onset to BMD measurement was shorter (P = 0.014) in osteoporotic patients than in non-osteoporotic patients. Function, as measured by modified Rankin scale score within 3 years of the BMD measurement, was worse in osteoporotic than in non-osteoporotic patients (P = 0.008). Discussion: BMD in CIDP patients was significantly lower than in normal controls. Functional status rather than cumulative steroid dose was associated with osteoporosis. Muscle Nerve 58: 407–412, 2018.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalMuscle and Nerve
Issue number3
Publication statusPublished - 2018 Sept

Bibliographical note

Funding Information:
Abbreviations: BMD, bone mineral density; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; DXA, dual-energy X-ray absorpti-ometry; MRC, Medical Research Council; mRS, modified Rankin scale Key words: bone mineral density; chronic inflammatory demyelinating polyradiculoneuropathy; corticosteroid; inflammatory neuropathy; osteoporosis Funding: National Research Foundation of Korea, grant NRF-2016R1C1B1010120.

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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