Rifamycin B. oxidase from Monocillium spp., a new type of diphenol oxidase

Moon H. Han, Seong Baik-Lin, Hyeung Jin Son, Mheen Tae-Ick

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


It was found that enzyme from a microbial strain, Monocillium spp. ATCC 20621, catalyzed the oxidative reaction of rifamycin B to form rifamycin O. The identification of the reaction products suggested that the reaction proceeded by the oxidative cyclization of rifamycin B to give rifamycin O, which spontaneously hydrolyzed to rifamycin S in neutral aqueous milieu. The characteristic of the enzyme was different as compared with that of other polyphenol oxidases such as laccase. It is proposed that this new type of enzyme be classified into a subgroup EC with a trival name rifamycin B oxidase.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalFEBS Letters
Issue number1
Publication statusPublished - 1983 Jan 10

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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