Rifabutin is active against mycobacterium abscessus in mice

Thomas Dick; Sung Jae Shin; Won Jung Koh; Véronique Dartois; Martin Gengenbacher

doi:10.1128/AAC.01943-19

Rifabutin is active against mycobacterium abscessus in mice

Thomas Dick, Sung Jae Shin, Won Jung Koh, Véronique Dartois, Martin Gengenbacher

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.

Original language	English
Article number	e01943
Journal	Antimicrobial agents and chemotherapy
Volume	64
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01943-19
Publication status	Published - 2020 Jan 27

Bibliographical note

Publisher Copyright:
© 2020 American Society for Microbiology. All rights reserved.

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01943-19

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abstract = "There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.",

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AU - Dartois, Véronique

AU - Gengenbacher, Martin

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AB - There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.

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Rifabutin is active against mycobacterium abscessus in mice

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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