Review on long-term non-renal complications of childhood nephrotic syndrome

Jiwon M. Lee, Andreas Kronbichler, Jae Il Shin, Jun Oh

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Background: Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much. Aim: We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up period of more than 10 years. Results: We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non-renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non-renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies. Conclusion: This review discusses and summarises the non-renal outcomes of idiopathic childhood NS.

Original languageEnglish
Pages (from-to)460-470
Number of pages11
JournalActa Paediatrica, International Journal of Paediatrics
Issue number3
Publication statusPublished - 2020 Mar 1

Bibliographical note

Publisher Copyright:
© 2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Review on long-term non-renal complications of childhood nephrotic syndrome'. Together they form a unique fingerprint.

Cite this