Retinal vein occlusion and the risk of acute myocardial infarction development: A 12-year nationwide cohort study

Tyler Hyungtaek Rim, John Seungsoo Han, Jaewon Oh, Dong Wook Kim, Seok Min Kang, Eun Jee Chung

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The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in 2002 were excluded. The RVO group was composed of patients who received an initial RVO diagnosis between January 2003 and December 2007 (n = 1677). The comparison group was selected (five patients per RVO patient; n = 8367) using propensity score matching according to sociodemographic factors and the year of enrolment. Each patient was tracked until 2013. The Cox proportional hazard regression model was used. AMI developed in 7.6% of the RVO group and 5.3% of the comparison group (p < 0.001) for 7.7 median follow-up periods. RVO increased the risk of AMI development [hazard ratio (HR) = 1.25; 95% Confidence Interval (CI) 1.02 to 1.52]. In the subgroup analysis, RVO patients aged <65 years and the males within this age group had an adjusted HR of 1.47 (95% CI 1.10 to 1.98) and an adjusted HR of 2.00 (95% CI 1.38 to 2.91) for AMI development, respectively. RVO was significantly associated with AMI development.

Original languageEnglish
Article number22351
JournalScientific reports
Publication statusPublished - 2016

Bibliographical note

Funding Information:
This study used the NHIS-NSC 2002–2013 database (NHIS–2015–2–034), which was released by the KNHIS. The authors alone are responsible for the content and writing of this paper.This work was supported by an NHIS (National Health Insurance Service) Ilsan Hospital grant (NHIMC 2014–20–005).

All Science Journal Classification (ASJC) codes

  • General


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