Responses of adipose-derived stem cells during hypoxia: Enhanced skin-regenerative potential

Hyung Min Chung, Chong Hyun Won, Jong Hyuk Sung

Research output: Contribution to journalReview articlepeer-review

82 Citations (Scopus)


Mesenchymal stem cells within the stromalvascular fraction of subcutaneous adipose tissue (i.e., adipose-derived stem cells (ASCs)), have been used for tissue engineering. In addition to serving a building-block function, ASCs are reported to secrete growth factors that are essential for their function. Increasing evidence indicates that ASCs play a significant role in skin regeneration, a function that is enhanced by hypoxia through upregulating secretion of growth factors. Although the anatomical sites of ASCs in the body are relatively oxygen-deficient, ASCs are usually cultured under normoxic conditions (i.e., atmospheric oxygen levels). Culturing ASCs under physiologically relevant low-oxygen-tension conditions may uniquely benefit the expansion, differentiation, adhesion, growth factor secretion and regenerative potential of ASCs. Therefore, understanding the response and adaptation of ASCs to hypoxia may be invaluable for developing novel cell- and cyto-therapy strategies. This review highlights our current understanding of cellular and molecular responses of ASCs to hypoxia, focusing on the enhancement of ASC function and secretory activity by hypoxic culture conditions.

Original languageEnglish
Pages (from-to)1499-1508
Number of pages10
JournalExpert Opinion on Biological Therapy
Issue number12
Publication statusPublished - 2009 Dec

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D project, Ministry for Health, Welfare & Family Affairs (A0851360).

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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