Response to switch from intermittent therapy to daily therapy for refractory nodular bronchiectatic Mycobacterium avium complex lung disease

Won Jung Koh; Byeong Ho Jeong; Kyeongman Jeon; Hye Yun Park; Su Young Kim; Hee Jae Huh; Chang Seok Ki; Nam Yong Lee; Sung Jae Shin; Charles L. Daley

doi:10.1128/AAC.00648-15

Response to switch from intermittent therapy to daily therapy for refractory nodular bronchiectatic Mycobacterium avium complex lung disease

Won Jung Koh, Byeong Ho Jeong, Kyeongman Jeon, Hye Yun Park, Su Young Kim, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L. Daley

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.

Original language	English
Pages (from-to)	4994-4996
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	59
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00648-15
Publication status	Published - 2015 Aug 1

Bibliographical note

Publisher Copyright:
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00648-15

Cite this

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title = "Response to switch from intermittent therapy to daily therapy for refractory nodular bronchiectatic Mycobacterium avium complex lung disease",

abstract = "Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.",

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AU - Koh, Won Jung

AU - Jeong, Byeong Ho

AU - Jeon, Kyeongman

AU - Park, Hye Yun

AU - Kim, Su Young

AU - Huh, Hee Jae

AU - Ki, Chang Seok

AU - Lee, Nam Yong

AU - Shin, Sung Jae

AU - Daley, Charles L.

PY - 2015/8/1

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Response to switch from intermittent therapy to daily therapy for refractory nodular bronchiectatic Mycobacterium avium complex lung disease

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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