Requirement of Rbp9 in the maintenance of Drosophila germline sexual identity

Sook Hee Lee, Young Joon Kim, Jeongsil Kim-Ha

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Drosophila germline sex determination is controlled by a group of genes expressed at early stages of oogenesis (ovo, otu, bam, and Sxl, etc.). Mutations in these genes cause not only sex transformation of female germ cells, but also ovarian tumors. Although mutations at the Rbp9 locus also cause an ovarian tumor phenotype, Rbp9 has been shown to function during later developmental stages than do other ovarian tumor-causing genes. To test whether Rbp9 is also required for germline sex determination, we examined the sex transformation process of female germ cells in Rbp9 mutant flies. The detection of Sxl male transcripts and other male germline markers in Rbp9 mutant ovaries revealed that the Rbp9 mutation caused a partial germline sex transformation. Therefore, sex determination signals that persist throughout oogenesis appear to be required for proper maintenance of germline sexual identity. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalFEBS Letters
Issue number2-3
Publication statusPublished - 2000 Jan 14

Bibliographical note

Funding Information:
We are grateful to S. DiNardo for providing the lacZ reporter strains. This work was supported by grants from SBRI (B-98-023) to J.K.-H. and Korea Science and Engineering Foundation, Republic of Korea (98-0403-04-01-5) to Y.-J.K. and J.K.-H.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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