TY - JOUR
T1 - Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population
AU - Yoon, Dankyu
AU - Ban, Hyo Jeong
AU - Kim, Young Jin
AU - Kim, Eun Jin
AU - Kim, Hyung Cheol
AU - Han, Bok Ghee
AU - Park, Jung Won
AU - Hong, Soo Jong
AU - Cho, Sang Heon
AU - Park, Kiejung
AU - Lee, Joo Shil
PY - 2012/5
Y1 - 2012/5
N2 - Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.
AB - Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.
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U2 - 10.5483/BMBRep.2012.45.5.305
DO - 10.5483/BMBRep.2012.45.5.305
M3 - Article
C2 - 22617455
AN - SCOPUS:84863446449
SN - 1976-6696
VL - 45
SP - 305
EP - 310
JO - BMB reports
JF - BMB reports
IS - 5
ER -