Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys

S. Lee; Y. Kim; D. A. White; J. L. Kuk; S. Arslanian

doi:10.1038/ejcn.2012.142

Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys

S. Lee, Y. Kim, D. A. White, J. L. Kuk, S. Arslanian

University College

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We examined the relationships between insulin sensitivity (IS), skeletal muscle (SM) mass and SM quality in youth. Forty obese adolescent boys (body mass index ≥95th percentile, 12-18 years) participated in this study. IS and glucose tolerance was measured by a 3 h hyperinsulinemiceuglycemic clamp and a 2 h oral glucose tolerance test (OGTT), total SM mass and intermusular adipose tissue (IMAT) by whole-body magnetic resonance imaging, and muscular strength by one-repetition maximum leg and bench press. IMAT was associated (P<0.05) with IS (r=-0.53) and OGTT-insulin area under the curve (AUC; r=0.31). Similarly, muscular strength was associated (P<0.05) with both IS (r=0.39) and OGTT-insulin AUC (r=0.32). By contrast, total SM mass was not associated with IS or any OGTT parameters (P>0.1). After accounting for race and tanner stage, IMAT and muscular strength remained significantly associated with IS, together explaining a total of 41% of the variance in IS. Our findings suggest that SM quality, but not SM mass, is associated with IS in obese adolescent boys.

Original language	English
Pages (from-to)	1366-1368
Number of pages	3
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	12
DOIs	https://doi.org/10.1038/ejcn.2012.142
Publication status	Published - 2012 Dec

Bibliographical note

Funding Information:
This research was funded by grants 7-08-JF-27 (Lee, American Diabetes Association Junior Faculty Award), Department of Defense (Lee and Arslanian), Children’s Hospital of Pittsburgh Cochrane-Weber Foundation (Lee) and UL1 RR024153 CTSA. The authors express their gratitude to the study participants and their parents, to Nancy Guerra and the PCTRC nursing staff for their excellent contributions. This work was presented at the Obesity Society Annual Meeting, October 1–5, 2011 in Orlando, FL, USA.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1038/ejcn.2012.142

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title = "Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys",

abstract = "We examined the relationships between insulin sensitivity (IS), skeletal muscle (SM) mass and SM quality in youth. Forty obese adolescent boys (body mass index ≥95th percentile, 12-18 years) participated in this study. IS and glucose tolerance was measured by a 3 h hyperinsulinemiceuglycemic clamp and a 2 h oral glucose tolerance test (OGTT), total SM mass and intermusular adipose tissue (IMAT) by whole-body magnetic resonance imaging, and muscular strength by one-repetition maximum leg and bench press. IMAT was associated (P<0.05) with IS (r=-0.53) and OGTT-insulin area under the curve (AUC; r=0.31). Similarly, muscular strength was associated (P<0.05) with both IS (r=0.39) and OGTT-insulin AUC (r=0.32). By contrast, total SM mass was not associated with IS or any OGTT parameters (P>0.1). After accounting for race and tanner stage, IMAT and muscular strength remained significantly associated with IS, together explaining a total of 41% of the variance in IS. Our findings suggest that SM quality, but not SM mass, is associated with IS in obese adolescent boys.",

author = "S. Lee and Y. Kim and White, {D. A.} and Kuk, {J. L.} and S. Arslanian",

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AU - White, D. A.

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AU - Arslanian, S.

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Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys

Abstract

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