Relation of inflammation and left atrial remodeling in atrial fibrillation occurring in early phase of acute myocardial infarction

Hye Jin Hwang, Jong Won Ha, Boyoung Joung, Eun Hee Choi, Jaedeok Kim, Min Soo Ahn, Moon Hyoung Lee, Yangsoo Jang, Namsik Chung, Sung Soon Kim

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25 Citations (Scopus)


Background: Inflammation is frequently associated with the development of atrial fibrillation (AF). This study was performed to investigate whether the high sensitivity C-reactive protein (hsCRP) present during acute inflammation could predict early AF and its relationship to left atrial (LA) enlargement in acute myocardial infarction (AMI). Methods and results: In 401 consecutive AMI patients, AF predictors were compared between those with and without early AF. Early AF was defined as AF developing within 24 h after AMI. In order to identify the difference in the AF predictors according to LA enlargement, patients were subgrouped according to an LA volume index (LAVI) of < 32 cm3/m2 (group 1, n = 321) and ≥ 32 cm 3/m2 (group 2, n = 80). Thirty-three (8.2%) patients developed early AF including 17 (5.3%) and 16 (20%) patients in groups 1 and 2, respectively. The independent predictors of AF were multivessel involvement (OR = 2.51, p = 0.03), LAVI ≥ 32 cm3/m2 (OR = 2.47, p = 0.03), higher hsCRP (OR = 2.24, p = 0.05), and old age (OR = 1.06, p = 0.01) in all patients. In the subgroups divided by the LAVI, higher hsCRP was a predictor of early AF only in group 1 (OR = 4.56, p = 0.004). Conclusions: Our results suggest that multivessel involvement, enlarged LA, higher hsCRP, and old age are predictors of early AF after AMI. However, hsCRP could be strongly related to early AF only in AMI patients with less dilated LA. Crown

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalInternational Journal of Cardiology
Issue number1
Publication statusPublished - 2011 Jan 7

Bibliographical note

Funding Information:
This study was supported by grants from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0412-CR02-0704-0001).

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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