Regulatory peptides desmopressin and glutathione voltammetric determination on nickel oxide modified electrodes

Sze Yin Chee; Martin Flegel; Martin Pumera

doi:10.1016/j.elecom.2011.06.012

Regulatory peptides desmopressin and glutathione voltammetric determination on nickel oxide modified electrodes

Sze Yin Chee, Martin Flegel, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The determination of important regulatory peptides containing disulphidic bridge and thiols are of much interest. We investigated, via differential pulse voltammetry, the use of glassy carbon electrodes modified with nickel(II) oxide nanoparticles for electrocatalytic oxidation of L-glutathione and desmopressin. Linear response in the range of 0.2 to 6.0 mM of L-glutathione was observed, which brackets the concentration of about 5 mM of L-glutathione in living cells. Hence electrochemical detection of L-glutathione can be achieved using the simple preparation of GC electrodes modified with inexpensive NiO nanoparticles.

Original language	English
Pages (from-to)	963-965
Number of pages	3
Journal	Electrochemistry Communications
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/j.elecom.2011.06.012
Publication status	Published - 2011 Sept

Bibliographical note

Funding Information:
M.P. thanks to Nanyang Assistant Professorship start-up fund (NTU). We wish to acknowledge the funding support for this project from Nanyang Technological University under the Undergraduate Research Experience on CAmpus (URECA) programme . M.F acknowledges funding from Grant MSM 0021620806 (Czech Republic).

All Science Journal Classification (ASJC) codes

Electrochemistry

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10.1016/j.elecom.2011.06.012

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abstract = "The determination of important regulatory peptides containing disulphidic bridge and thiols are of much interest. We investigated, via differential pulse voltammetry, the use of glassy carbon electrodes modified with nickel(II) oxide nanoparticles for electrocatalytic oxidation of L-glutathione and desmopressin. Linear response in the range of 0.2 to 6.0 mM of L-glutathione was observed, which brackets the concentration of about 5 mM of L-glutathione in living cells. Hence electrochemical detection of L-glutathione can be achieved using the simple preparation of GC electrodes modified with inexpensive NiO nanoparticles.",

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AU - Pumera, Martin

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AB - The determination of important regulatory peptides containing disulphidic bridge and thiols are of much interest. We investigated, via differential pulse voltammetry, the use of glassy carbon electrodes modified with nickel(II) oxide nanoparticles for electrocatalytic oxidation of L-glutathione and desmopressin. Linear response in the range of 0.2 to 6.0 mM of L-glutathione was observed, which brackets the concentration of about 5 mM of L-glutathione in living cells. Hence electrochemical detection of L-glutathione can be achieved using the simple preparation of GC electrodes modified with inexpensive NiO nanoparticles.

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Regulatory peptides desmopressin and glutathione voltammetric determination on nickel oxide modified electrodes

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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