Regulation of stomatal development by stomatal lineage miRNAs

Jiali Zhu, Ji Hwan Park, Seulbee Lee, Jae Ho Lee, Daehee Hwang, June M. Kwak, Yun Ju Kim

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Stomata in the plant epidermis play a critical role in growth and survival by controlling gas exchange, transpiration, and immunity to pathogens. Plants modulate stomatal cell fate and patterning through key transcriptional factors and signaling pathways. MicroRNAs (miRNAs) are known to contribute to developmental plasticity in multicellular organisms; however, no miRNAs appear to target the known regulators of stomatal development. It remains unclear as to whether miRNAs are involved in stomatal development. Here, we report highly dynamic, developmentally stage-specific miRNA expression profiles from stomatal lineage cells. We demonstrate that stomatal lineage miRNAs positively and negatively regulate stomatal formation and patterning to avoid clustered stomata. Target prediction of stomatal lineage miRNAs implicates potential cellular processes in stomatal development. We show that miR399-mediated PHO2 regulation, involved in phosphate homeostasis, contributes to the control of stomatal development. Our study demonstrates that miRNAs constitute a critical component in the regulatory mechanisms controlling stomatal development.

Original languageEnglish
Pages (from-to)6237-6245
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number11
Publication statusPublished - 2020 Mar 17

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© 2020 National Academy of Sciences. All rights reserved.

All Science Journal Classification (ASJC) codes

  • General


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