Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

Donghyuk Shin; Rukmini Mukherjee; Yaobin Liu; Alexis Gonzalez; Florian Bonn; Yan Liu; Vladimir V. Rogov; Marcel Heinz; Alexandra Stolz; Gerhard Hummer; Volker Dötsch; Zhao Qing Luo; Sagar Bhogaraju; Ivan Dikic

doi:10.1016/j.molcel.2019.10.019

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

Donghyuk Shin, Rukmini Mukherjee, Yaobin Liu, Alexis Gonzalez, Florian Bonn, Yan Liu, Vladimir V. Rogov, Marcel Heinz, Alexandra Stolz, Gerhard Hummer, Volker Dötsch, Zhao Qing Luo, Sagar Bhogaraju, Ivan Dikic

Division of Life Sciences

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92 Citations (Scopus)

Abstract

Shin et al. show that phosphoribosyl serine ubiquitination can be reversed by two deubiquitinases (DupA and DupB) from Legionella. Two DUPs specifically cleave PR-ubiquitin from serine on substrates. Catalytically inactive DupA-based proteomics approach reveals PR-ubiquitinated proteins and their roles in endoplasmic reticulum (ER) remodeling.

Original language	English
Pages (from-to)	164-179.e6
Journal	Molecular Cell
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2019.10.019
Publication status	Published - 2020 Jan 2

Bibliographical note

Publisher Copyright:
© 2019 The Authors

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.10.019

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title = "Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB",

abstract = "Shin et al. show that phosphoribosyl serine ubiquitination can be reversed by two deubiquitinases (DupA and DupB) from Legionella. Two DUPs specifically cleave PR-ubiquitin from serine on substrates. Catalytically inactive DupA-based proteomics approach reveals PR-ubiquitinated proteins and their roles in endoplasmic reticulum (ER) remodeling.",

keywords = "ADP-ribosylation, ER-fragmentation, Legionella pneumophila, SdeA, deubiquitinase, deubiquitination, endoplasmic reticulum, phosphodiesterase, phosphoribosyl serine ubiquitination",

author = "Donghyuk Shin and Rukmini Mukherjee and Yaobin Liu and Alexis Gonzalez and Florian Bonn and Yan Liu and Rogov, {Vladimir V.} and Marcel Heinz and Alexandra Stolz and Gerhard Hummer and Volker D{\"o}tsch and Luo, {Zhao Qing} and Sagar Bhogaraju and Ivan Dikic",

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doi = "10.1016/j.molcel.2019.10.019",

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T1 - Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

AU - Shin, Donghyuk

AU - Mukherjee, Rukmini

AU - Liu, Yaobin

AU - Gonzalez, Alexis

AU - Bonn, Florian

AU - Liu, Yan

AU - Rogov, Vladimir V.

AU - Heinz, Marcel

AU - Stolz, Alexandra

AU - Hummer, Gerhard

AU - Dötsch, Volker

AU - Luo, Zhao Qing

AU - Bhogaraju, Sagar

AU - Dikic, Ivan

PY - 2020/1/2

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N2 - Shin et al. show that phosphoribosyl serine ubiquitination can be reversed by two deubiquitinases (DupA and DupB) from Legionella. Two DUPs specifically cleave PR-ubiquitin from serine on substrates. Catalytically inactive DupA-based proteomics approach reveals PR-ubiquitinated proteins and their roles in endoplasmic reticulum (ER) remodeling.

AB - Shin et al. show that phosphoribosyl serine ubiquitination can be reversed by two deubiquitinases (DupA and DupB) from Legionella. Two DUPs specifically cleave PR-ubiquitin from serine on substrates. Catalytically inactive DupA-based proteomics approach reveals PR-ubiquitinated proteins and their roles in endoplasmic reticulum (ER) remodeling.

KW - ADP-ribosylation

KW - ER-fragmentation

KW - Legionella pneumophila

KW - SdeA

KW - deubiquitinase

KW - deubiquitination

KW - endoplasmic reticulum

KW - phosphodiesterase

KW - phosphoribosyl serine ubiquitination

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Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

Abstract

Bibliographical note

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