Regulation of Escherichia coli pyrC by the purine regulon repressor protein

K. Y. Choi, H. Zalkin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The purine regulon repressor, PurR, was identified as a component of the Escherichia coli regulatory system for pyrC, the gene that encodes dihydroorotase, an enzyme in the novo pyrimidine nucleotide synthesis. PurR binds to a pyrC control site that resembles a pur regulon operator and represses expression by twofold. Mutations that increase binding of PurR to the control site in vitro concomitantly increase in vivo regulation. There are completely independent mechanisms for regulation of pyrC by purine and pyrimidine nucleotides. Cross pathway regulation of pyrC by PurR may provide one mechanism to coordinate synthesis of purine and pyrimidine nucleotides.

Original languageEnglish
Pages (from-to)3201-3207
Number of pages7
JournalJournal of Bacteriology
Issue number6
Publication statusPublished - 1990

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology


Dive into the research topics of 'Regulation of Escherichia coli pyrC by the purine regulon repressor protein'. Together they form a unique fingerprint.

Cite this