Reference values of impulse oscillometry and its utility in the diagnosis of asthma in young Korean children

Jung Yong Lee, Ju Hee Seo, Hyung Young Kim, Young Ho Jung, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, So Yeon Lee, Gwang Cheon Jang, Dae Jin Song, Woo Kyung Kim, Jung Yeon Shim, Ha Jung Kim, Yee Jin Shin, Jung Won Park, Sang Heon Cho, Joo Shil Lee, Soo Jong Hong

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27 Citations (Scopus)


Aims. The aims of this study were (1) to determine the reference values for impulse oscillometry (IOS) and (2) to apply them to the evaluation of asthma in the general population of young Korean children. Methods. We performed a questionnaire survey and IOS measurements in 390 children aged 37 years in Seoul and Gyeonggi province, Korea, from July to August 2010. IOS measurements included respiratory resistance (Rrs) and respiratory reactance (Xrs) at 5, 10, 15, 20, 25, and 35 Hz, respiratory impedance (Zrs), and resonance frequency (RF) before and 15 min after inhalation of 200 μg salbutamol. To determine the reference values for IOS, 161 children defined as healthy controls were assessed. Results. The IOS measurements were presented as means and standard deviations. The reference equations for IOS variables were determined by multiple linear regression analysis taking into account their height, weight, and age (R5 2.242 0.008 × height (cm) 0.005 × age (months), coefficients of determination (R2) 0.213). Height had the greatest correlation with IOS variables, similar to previous studies. Positive airway obstruction was defined as R5 greater than the 95th percentile of predicted R5 from the reference equation. There was a higher percentage of children with positive airway obstruction in children with asthma than in healthy controls (27.3 vs. 6.2). Multivariate logistic regression analysis indicated that positive airway obstruction was a significant risk factor for the diagnosis of asthma (adjusted odds ratio (aOR), 6.245; 95 confidence interval (CI), 2.27017.175). Conclusion. This study provided reference values for IOS in young Korean children and applied the reference values to evaluate children with asthma. We suggest the 95th percentile of predicted R5 as a cut-off value for positive airway obstruction, which may increase the risk for diagnosis of asthma.

Original languageEnglish
Pages (from-to)811-816
Number of pages6
JournalJournal of Asthma
Issue number8
Publication statusPublished - 2012 Oct

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, Republic of Korea (A092076).

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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