Reduction of noise amplification in SPECT using smaller detector bin size

Do Sik Hwang, Gengsheng L. Zeng

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


In SPECT iterative reconstruction methods, such as the ML-EM (Maximum Likelihood Expectation Maximization) algorithm, the noise propagation from the projection measurements into the reconstructed image has been a difficult problem to control as the algorithm iterates. In this paper, we show that the noise amplification can be reduced by using a detector whose bin size is smaller than the image pixel size without applying any regularization methods or changing any other factors. We compare different detector system characteristics using SVD (Singular Value Decomposition) analysis, show the noise properties in each detector system through both simulation studies and physical phantom studies, and finally compare how the noise amplification affects the image quality in different detector systems. The ML-EM algorithm when used in conjunction with a smaller detector bin size has better convergent properties, reduces noise amplification, and produces better image quality.

Original languageEnglish
Pages (from-to)2543-2547
Number of pages5
JournalIEEE Nuclear Science Symposium Conference Record
Publication statusPublished - 2004
Event2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy
Duration: 2004 Oct 162004 Oct 22

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Reduction of noise amplification in SPECT using smaller detector bin size'. Together they form a unique fingerprint.

Cite this