Redox signaling by ionizing radiation in mouse liver

Jeung Hee An, Jiyoung Kim, Jinsil Seong

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Since radiation treatment has been reappraised in the treatment of hepatic tumors, radiation response in the liver is emerging as an interesting new area of investigation. In this study, identification of the repertoire of signaling proteins was performed using a proteomics approach involving cellular responses of liver tissue to ionizing radiation. Approximately 800 protein spots were detected. Among them, at least 28 proteins showed significant quantitative alterations after radiation. The significantly altered proteins were categorized as those related to reactive oxygen species (ROS) metabolism, metabolic pathway proteins, and G-type proteins. Particularly, the expression levels of proteins related to ROS metabolism, including cytochrome c, glutathione S-transferase Pi, NADH dehydrogenase, and peroxiredoxin VI, were increased after radiation. It is suggested that although radiation initiates cytotoxic effects, it can also induce a radioprotective antioxidant system.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


Dive into the research topics of 'Redox signaling by ionizing radiation in mouse liver'. Together they form a unique fingerprint.

Cite this