Recombinant batroxobin-coated nonwoven chitosan as hemostatic dressing for initial hemorrhage control

Gyeung Mi Seon, Mi Hee Lee, Byeong Ju Kwon, Min Sung Kim, Min Ah Koo, Young Seomun, Jong Tak Kim, Tae Hee Kim, Jong Chul Park

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The choice of hemostat is determined by the situation and the degree of hemorrhage. One common hemostat, the nonwoven dressing, is easy to handled and controls severe bleeding on wider wounds. In this study, chitosan-based nonwoven dressings with recombinant batroxobin (rBat) were used as efficacious hemostatic dressing agents. Hemostatic agents need to absorb blood quickly in the early stages of blood coagulation cascade to rapidly and effectively control of excessive hemorrhages. To date, most studies of hemostatic agents focused on a single material and hemostats composed of multiple materials have not been studied sufficiently. Thus, we made a chitosan dressing coated with rBat and investigated the microstructure, mechanical properties, hemostatic efficacy, and clotting properties of the coated dressing. Our results showed that the rBat had a synergetic effect on chitosan that improved blood coagulation. Furthermore, the dressing had excellent bleeding control in an Sprague-Dawley (SD) rat femoral artery hemorrhage model. In conclusion, hemostasis can be improved by combining a chitosan-based nonwoven dressing with other agents, and rBat-coated chitosan-based nonwoven dressings have enormous potential to improve blood coagulation.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - 2018 Jul 1

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology
  • Biochemistry


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