Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Hyun Yoo; Byeongwook Jeon; Myung Shin Jeon; Hyangkyu Lee; Tae Yoon Kim

doi:10.1016/j.febslet.2008.08.017

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Hyun Yoo, Byeongwook Jeon, Myung Shin Jeon, Hyangkyu Lee, Tae Yoon Kim

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Abstract

The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

Original language	English
Pages (from-to)	3249-3253
Number of pages	5
Journal	FEBS Letters
Volume	582
Issue number	21-22
DOIs	https://doi.org/10.1016/j.febslet.2008.08.017
Publication status	Published - 2008 Sept 22

Bibliographical note

Funding Information:
This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2008.08.017

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@article{49c08030a1fd439683e689d88a4e0378,

title = "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes",

abstract = "The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.",

author = "Hyun Yoo and Byeongwook Jeon and Jeon, {Myung Shin} and Hyangkyu Lee and Kim, {Tae Yoon}",

note = "Funding Information: This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.",

year = "2008",

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doi = "10.1016/j.febslet.2008.08.017",

language = "English",

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T1 - Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

AU - Yoo, Hyun

AU - Jeon, Byeongwook

AU - Jeon, Myung Shin

AU - Lee, Hyangkyu

AU - Kim, Tae Yoon

N1 - Funding Information: This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.

PY - 2008/9/22

Y1 - 2008/9/22

N2 - The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

AB - The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

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SP - 3249

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JO - FEBS Letters

JF - FEBS Letters

IS - 21-22

ER -

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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