TY - JOUR
T1 - Recent advances in understanding peripheral taste decoding i
T2 - 2010 to 2020
AU - Jang, Jea Hwa
AU - Kwon, Obin
AU - Moon, Seok Jun
AU - Jeong, Yong Taek
N1 - Publisher Copyright:
© 2021 Korean Endocrine Society.
PY - 2021/6
Y1 - 2021/6
N2 - Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by sweet and umami tastes, respectively, whereas noxious substances and toxins by bitter or sour tastes. Essential electrolytes including Na+ and other ions are recognized by the salty taste. Gustatory information is initially generated by taste buds in the oral cavity, projected into the central nervous system, and finally processed to provide input signals for food recognition, regulation of metabolism and physiology, and higher-order brain functions such as learning and memory, emotion, and reward. Therefore, understanding the peripheral taste system is fundamental for the development of technologies to regulate the endocrine system and improve whole-body metabolism. In this review article, we introduce previous widely-accepted views on the physiology and genetics of peripheral taste cells and primary gustatory neurons, and discuss key findings from the past decade that have raised novel questions or solved previously raised questions.
AB - Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by sweet and umami tastes, respectively, whereas noxious substances and toxins by bitter or sour tastes. Essential electrolytes including Na+ and other ions are recognized by the salty taste. Gustatory information is initially generated by taste buds in the oral cavity, projected into the central nervous system, and finally processed to provide input signals for food recognition, regulation of metabolism and physiology, and higher-order brain functions such as learning and memory, emotion, and reward. Therefore, understanding the peripheral taste system is fundamental for the development of technologies to regulate the endocrine system and improve whole-body metabolism. In this review article, we introduce previous widely-accepted views on the physiology and genetics of peripheral taste cells and primary gustatory neurons, and discuss key findings from the past decade that have raised novel questions or solved previously raised questions.
KW - Geniculate ganglion
KW - Hormones
KW - Signal transduction
KW - Synaptic transmission
KW - Taste
KW - Taste buds
UR - http://www.scopus.com/inward/record.url?scp=85109488357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85109488357&partnerID=8YFLogxK
U2 - 10.3803/ENM.2021.302
DO - 10.3803/ENM.2021.302
M3 - Article
C2 - 34139798
AN - SCOPUS:85109488357
SN - 2093-596X
VL - 36
SP - 469
EP - 477
JO - Endocrinology and Metabolism
JF - Endocrinology and Metabolism
IS - 3
ER -