Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Jun Chen; Xixi Zhang; Reid Millican; Jennifer Sherwood; Sean Martin; Hanjoong Jo; Young sup Yoon; Brigitta C. Brott; Ho Wook Jun

doi:10.1016/j.addr.2021.01.005

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Jun Chen, Xixi Zhang, Reid Millican, Jennifer Sherwood, Sean Martin, Hanjoong Jo, Young sup Yoon, Brigitta C. Brott, Ho Wook Jun

BioMedical Science Institute

Research output: Contribution to journal › Review article › peer-review

64 Citations (Scopus)

Abstract

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.

Original language	English
Pages (from-to)	142-199
Number of pages	58
Journal	Advanced Drug Delivery Reviews
Volume	170
DOIs	https://doi.org/10.1016/j.addr.2021.01.005
Publication status	Published - 2021 Mar

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© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1016/j.addr.2021.01.005

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title = "Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis",

abstract = "Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.",

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AU - Chen, Jun

AU - Zhang, Xixi

AU - Millican, Reid

AU - Sherwood, Jennifer

AU - Martin, Sean

AU - Jo, Hanjoong

AU - Yoon, Young sup

AU - Brott, Brigitta C.

AU - Jun, Ho Wook

PY - 2021/3

Y1 - 2021/3

N2 - Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.

AB - Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.

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Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Abstract

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