Recent advances in electronic devices for monitoring and modulation of brain

Yong Won Kwon, Yoon Sun Jun, Young Geun Park, Jiuk Jang, Jang Ung Park

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


The brain is actuated by billions of neurons with trillions of interconnections that regulate human behaviors. Understanding the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science, engineering, and medicine. Recent advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brain’s complex nervous system. The development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in parallel. In addition, these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral tissues. Here, we review the progress of electronic devices interfacing with brain in terms of the materials, fabrication technologies, and device designs. Neurophysiological activity can be measured and modulated by brain probes based on newly developed nanofabrication methodologies. Furthermore, in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless form. We also consider the key challenges and prospects for further development, and explore the future directions emerging in the latest research. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)3070-3095
Number of pages26
JournalNano Research
Issue number9
Publication statusPublished - 2021 Sept

Bibliographical note

Publisher Copyright:
© 2021, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • General Materials Science
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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