Randomized comparisons between different stenting approaches for bifurcation coronary lesions with or without side branch stenosis

Young Hak Kim, Jae Hwan Lee, Jae Hyung Roh, Jung Min Ahn, Sung Han Yoon, Duk Woo Park, Jong Young Lee, Sung Cheol Yun, Soo Jin Kang, Seung Whan Lee, Cheol Whan Lee, Ki Bae Seung, Won Yong Shin, Nae Hee Lee, Bong Ki Lee, Sang Gon Lee, Chang Wook Nam, Junghan Yoon, Joo Young Yang, Min Su HyonKeun Lee, Jae Sik Jang, Hyun Sook Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Objectives This study sought to evaluate the optimal percutaneous coronary intervention techniques using drug-eluting stents for bifurcation coronary lesions. Background The optimal bifurcation stenting technique needs to be evaluated. Methods The trial included 2 randomization studies separated by the presence of side branch (SB) stenosis for patients having non-left main bifurcation lesions. For 306 patients without SB stenosis, the routine final kissing balloon or leave-alone approaches were compared. Another randomization study compared the crush or single-stent approaches for 419 patients with SB stenosis. Results Between the routine final kissing balloon and leave-alone groups for nondiseased SB lesions, angiographic restenosis occurred in 17.9% versus 9.3% (p = 0.064), comprising 15.1% versus 3.7% for the main branch (p = 0.004) and 2.8% versus 5.6% for the SB (p = 0.50) from 214 patients (69.9%) receiving 8-month angiographic follow-up. Incidence of major adverse cardiac events including death, myocardial infarction, or target vessel revascularization over 1 year was 14.0% versus 11.6% between the routine final kissing balloon and leave-alone groups (p = 0.57). In another randomization study for diseased SB lesions, 28.2% in the single-stent group received SB stents. From 300 patients (71.6%) receiving angiographic follow-up, between the crush and single-stent groups, angiographic restenosis rate was 8.4% versus 11.0% (p = 0.44), comprising 5.2% versus 4.8% for the main branch (p = 0.90) and 3.9% versus 8.3% for the SB (p = 0.12). One-year major adverse cardiac events rate between the crush and single-stent groups was 17.9% versus 18.5% (p = 0.84). Conclusions Angiographic and clinical outcomes were excellent after percutaneous coronary intervention using drug-eluting stents with any stent technique for non-left main bifurcation lesions once the procedure was performed successfully.

Original languageEnglish
Pages (from-to)550-560
Number of pages11
JournalJACC: Cardiovascular Interventions
Issue number4
Publication statusPublished - 2015 Apr 20

Bibliographical note

Funding Information:
This study was partly supported by a grant from the Korean Society of Interventional Cardiology (2008-1) and Korea Healthcare Technology R&D Project , Ministry of Health and Welfare , Republic of Korea (HI12C0630, HI10C2020, and HI10C2020). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2015 American College of Cardiology Foundation.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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