Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study

Nitin Ohri, Laura A. Dawson, Sunil Krishnan, Jinsil Seong, Jason C. Cheng, Shiv K. Sarin, Milan Kinkhabwala, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Chandan Guha

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)


Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

Original languageEnglish
Article numberdjw133
JournalJournal of the National Cancer Institute
Issue number9
Publication statusPublished - 2016 Sept 1

Bibliographical note

Publisher Copyright:
© 2016 The Author 2016. Published by Oxford University Press. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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