Radio frequency based label-free detection of glucose

Hyunggoo Park, Hyung Seo Yoon, Umakant Patil, Rani Anoop, Juho Lee, Juhwan Lim, Woonhyoung Lee, Seong Chan Jun

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


We investigated the frequency based mediator-free glucose sensor in the radio-frequency (RF) range. Frequency dependent power signal showed clear dependence on the glucose concentration with free enzymatic condition. Also, the passive electrical components such as the resistance, inductance, shunt conductance, and capacitance were extracted based on the transmission line model for further analysis. These various parameters proposed by the signal processing provided more effective verification for instant multi-components in-situ readings without any added supporters. Additionally the residual signal (RS), impedance (Z), and propagation constant (γ) were also calculated from measured S-parameters for glucose analysis. These parameters basically showed amplitude variation and interestingly, some parameters such as inductance and impedance showed frequency shift of resonance dip. The results support that the frequency based sensing technique including the parameter based analysis can enable effective multi-dimensional detection of glucose. Moreover, this technique showed that glucose sensing is also possible over a diabetic patient's serum.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalBiosensors and Bioelectronics
Publication statusPublished - 2014 Apr 15

Bibliographical note

Funding Information:
This research was partially supported by the Priority Research Centers Program ( 2012-8-1663 ), the Pioneer Research Center Program ( 2012-0000428 ), and the Basic Science Research Program ( 2012-8-0622 ) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of the Korean government .

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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