Rab25 as a tumour suppressor in colon carcinogenesis

J. R. Goldenring; K. T. Nam

doi:10.1038/sj.bjc.6605983

Rab25 as a tumour suppressor in colon carcinogenesis

J. R. Goldenring, K. T. Nam

BioMedical Science Institute

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

Abstract

Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in human colon cancers independent of stage. Recent studies of mouse models of intestinal and colonic neoplasia have demonstrated that Rab25 deficiency markedly promotes the development of neoplasia. Some of these effects appear related to alterations in Β1-integrin trafficking to the cell surface. These findings all suggest that Rab25 is a tumour suppressor for colonic neoplasia.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	British journal of cancer
Volume	104
Issue number	1
DOIs	https://doi.org/10.1038/sj.bjc.6605983
Publication status	Published - 2011 Jan 4

Bibliographical note

Funding Information:
Dr Goldenring is supported by the NIH Grants RO1 DK48370 and R21 AR49311 and a VA Merit Review award.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605983

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Rab25 as a tumour suppressor in colon carcinogenesis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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