Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Jung Hoon Lee; Yong Beom Lim; Joon Sig Choi; Myung Un Choi; Chul Hak Yang; Jong Sang Park

doi:10.5012/bkcs.2003.24.11.1637

Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Jung Hoon Lee, Yong Beom Lim, Joon Sig Choi, Myung Un Choi, Chul Hak Yang, Jong Sang Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

Original language	English
Pages (from-to)	1637-1640
Number of pages	4
Journal	Bulletin of the Korean Chemical Society
Volume	24
Issue number	11
DOIs	https://doi.org/10.5012/bkcs.2003.24.11.1637
Publication status	Published - 2003 Nov 20

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.5012/bkcs.2003.24.11.1637

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AU - Choi, Myung Un

AU - Yang, Chul Hak

AU - Park, Jong Sang

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Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Abstract

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