Quantitative Interpretation of Hydration Dynamics Enabled the Fabrication of a Zwitterionic Antifouling Surface

Woojin Choi, Jie Jin, Sohyeon Park, Ji Yeong Kim, Myung Jin Lee, Hyeongdeok Sun, Jae Sung Kwon, Hwankyu Lee, Sung Hwan Choi, Jinkee Hong

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


In the medical industry, zwitterionic brushes have received significant attention owing to their antifouling effect that arose from their hydration ability. However, sufficient understanding of the hydration dynamics of zwitterionic brushes is required to fabricate the precisely controlled antifouling medical devices. In this paper, we successfully show that hydration, the interaction between water molecules and zwitterionic brushes, and its dynamics can be evaluated logically and quantitatively using (i) water contact angle, (ii) molecular dynamics simulation, and (iii) Raman spectroscopy. Based on the intuitive results on hydration, we precisely optimized the antifouling property of the model medical device, a removable orthodontic retainer, with various grafting efficiencies of 2-methacryloyloxyethyl phosphate choline. As a result, the model device reduced nonspecific adsorption of proteins and bacteria, indicating an improved antifouling effect, and also inhibited the formation of a biofilm. Furthermore, the device showed excellent physical properties desirable for application in the orthodontic field, meaning the balance between the antibacterial property and mechanical strength.

Original languageEnglish
Pages (from-to)7951-7965
Number of pages15
JournalACS Applied Materials and Interfaces
Issue number7
Publication statusPublished - 2020 Feb 19

Bibliographical note

Funding Information:
The authors confirm that there are no known conflicts of interest associated with this publication. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1E1A1A01074343, NRF-2018R1C1B6000989 and NRF-2017R1D1A1A09000510).

Publisher Copyright:
Copyright © 2020 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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