Pseudopolymorphic crystallization of L-ornithine-L-aspartate by drowning out

Yehoon Kim, Seungjoo Haam, Yong Gun Shul, Woo Sik Kim, Joon Ki Jung, Hee Chun Eun, Kee Kahb Koo

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17 Citations (Scopus)


Crystallization of L-ornithine-L-aspartate (LOLA) by drowning out was investigated using methanol as an antisolvent for the production of the anhydrous form of LOLA. An initial mixing method of the LOLA aqueous solution with methanol was found to be a critical factor in the pseudopolymorphic crystallization of LOLA. When methanol was added into the LOLA aqueous solution, it was found that the crystal structure of LOLA was mainly determined by the operating temperature. At a temperature higher than about 60 °C, the anhydrous form of LOLA was always formed. However, at a temperature lower than 50 °C, only LOLA hydrate was produced. On the other hand, when the LOLA aqueous solution was added into methanol, the anhydrous form was obtained by controlling the operational temperature, the feeding rate of the LOLA aqueous solution, and the methanol concentration even at a temperature lower than 50 °C.

Original languageEnglish
Pages (from-to)883-889
Number of pages7
JournalIndustrial and Engineering Chemistry Research
Issue number4
Publication statusPublished - 2003 Feb 19

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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