Proprioceptive training and outcomes of patients with knee osteoarthritis: A meta-analysis of randomized controlled trials

Hee Seong Jeong, Sung Cheol Lee, Hyunseok Jee, Jun Bom Song, Hyun Sik Chang, Sae Yong Lee

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26 Citations (Scopus)


Objective: To describe the effects of proprioceptive training on pain, stiffness, function, and functional test outcomes among patients with knee osteoarthritis (OA). Data Sources: All studies completed from 1946 to 2017 were obtained from 4 databases (PubMed, MEDLINE, CINAHL, and SPORTDiscus). Study Selection: Three reviewers independently identified appropriate studies and extracted data. Data Extraction: Methodologic quality and level of evidence were assessed using the Physiotherapy Evidence Database scale and Oxford Centre for Evidence-Based Medicine guidelines. The standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for pain, stiffness, function, and functional test outcomes. Data Synthesis: Seven randomized controlled trials involving 558 patients with knee OA met the inclusion criteria. The selected studies had Physiotherapy Evidence Database scores of 6 to 8. All randomized controlled trials had an Oxford Centre for Evidence-Based Medicine level of evidence of 2. Meta-analysis of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (SMD ¼ 0.56; 95% CI ¼ 1.06, 0.07; P ¼ .026), function subscale (SMD ¼ 0.40; 95% CI ¼ 0.59, 0.21; P, .001), and non-WOMAC walking speed test (SMD ¼ 1.07; 95% CI ¼ 2.12, 0.01; P ¼ .048) revealed that proprioceptive training had significant treatment effects. Proprioceptive training was not associated with reductions in WOMAC stiffness subscale scores and did not improve non-WOMAC get-up-and-go scores. Conclusions: Proprioceptive training effectively promoted pain relief and completion of functional daily activity among patients with knee OA and should be included in rehabilitation programs. Stiffness and other mobility measures were unchanged after proprioceptive training. Modified proprioceptive training programs are needed to target stiffness and improve additional physical function domains.

Original languageEnglish
Pages (from-to)418-428
Number of pages11
JournalJournal of Athletic Training
Issue number4
Publication statusPublished - 2019 Apr

Bibliographical note

Funding Information:
This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2015S1A5B8036349) and partly supported by the Yonsei Institute of Sports Science and Exercise Medicine (YISSEM 2015-51-0455), which is an International Olympic Committee International Research Centre for Prevention of Injury and Protection of Athlete Health.

Publisher Copyright:
© by the National Athletic Trainers’ Association, Inc.

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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